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Preliminary evidence suggests that vitamin B6 supplementationat such doses as 50350 mg/day in children and 50100 mg/day in adults might reduce these side effects

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These abnormalities lead to a reduction in the removal of lactate from the blood and the inhibition of pyruvate dehydrogenase (PDH), an enzyme that converts pyruvate to acetyl-CoA

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In hypertension, increased vascular 20-HETE production contributes to vasoconstriction and elevated peripheral resistance, and urinary 20-HETE is elevated in salt-sensitive hypertension models