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Funding: Open Access publication was supported by an unrestricted donation from Pure Encapsulations, Sudbury, MA, USA

ALS pathology involves degeneration of upper and lower motor neurons, misfolded protein accumulation (e.g., TDP-43), mitochondrial dysfunction, oxidative stress, neuroinflammation, and excitotoxicity [100]

[DOI] [PubMed] [Google Scholar] 186.Cappuccio FP, et al

10.1016/s0306-4522(00)00317-1 82 ChoiB

However, another randomized, double-blind, placebo-controlled trial in 181 patients with diabetic neuropathy found that oral supplementation with either 600 mg/day, 1,200 mg/day, or 1,800 mg/day of lipoic acid for five weeks significantly improved neuropathic symptoms (77)
