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Firmicutes and Bacteroides are the predominant residential communities which are present in healthy individuals, whereas during dysbiosis of the gut in IBD patients, altered levels of predominant community and expansion in the level of Enterobacteriaceae family have been observed

Aluminum toxicity is well documented, but the mechanism of action is poorly understood [48]

Despite these strengths, RCTs face important limitations

Olokizumab, a monoclonal antibody against interleukin-6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by tumour necrosis factor inhibitor therapy: efficacy and safety results of a randomised controlled phase III study

This inhibition is likely to influence electrolyte balance in the mucosal layer and may diminish the efficacy of immunological components that are sensitive to pH alterations (Keszthelyi et al