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XDH can transform into XO through the thiol oxidation, and the formation of a disulfide bond or proteolysis can then lock the enzyme in the XO form [Nishino et al ., 2008]

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Dihexa acetate can amplify the binding efficiency of HGF and c-Met receptors in vivo with high affinity, activate downstream Akt and ERK cell survival signaling pathways, inhibit neuronal apoptosis, accelerate the generation of new synaptic structures, and remodel the brain's neural synaptic network structure