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doi: 10.1007/s12975-019-00712-z 22 DruryP

SARS-CoV-2 nsp12 is composed of three major domains, a nidovirus RdRP-associated nucleotidyltransferase (NiRAN) domain, an interface domain and a right-handed RdRP domain (finger, palm and thumb) 111 (Fig

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In biological systems, redox reactions occur through the transfer of electrons from reduced donor molecules (including NADPH and thiols in reduced glutathione (GSH) and the amino acid cysteine found in many proteins) to acceptor molecules (such as NADP+ and disulfide bonds in cysteine, the oxidized dimeric form of cysteine) 5

Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs
