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Use of aspirin as a cardioprotective agent for treating atherosclerosis can be considered as the oldest and most classical example of using an anti-inflammatory drug for cardiovascular disease
You have G6PD deficiency or a history of kidney stones and are considering high-dose vitamin C, which warrants special caution and clinician oversight

2 , 10 However, the gastrointestinal adverse effects associated with oral therapy are a substantial disadvantage, notably if this results in a longer time for drug absorption and hence a longer time to reach therapeutic effect

Liver 22(3):205-12, 2002

These approaches improve intestinal barrier integrity, reduce endotoxemia, and inhibit hepatic inflammatory pathways (via TLR4/NF-B), thereby attenuating disease progression [72]