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CS contains thousands of reactive oxidants and free radicals, directly imposing oxidative stress on pulmonary cells

The activated Nrf2-sMaf heterodimer binds to antioxidant response element (ARE) sequences in the promoter of a tandem of antioxidant genes, including heme oxygenase-1 (HMOX1), aldo-keto reductases, glutathione, and glutathione-S-transferase (Tonelli et al., 2018), to trigger their expression

The mechanism by which IGF-1R signaling mediates radioresistance is thought to be associated with diminished -H2AX foci, which normally promote the resolution of irradiation-induced DNA double-strand breaks (DSBs) via both homologous recombination (HR) and the classical nonhomologous end joining (C-NHEJ) pathway (Figure 2) [41]

The Lamkin Clinic in Edmond serves patients across the Oklahoma City metro with individualized, lab-based weight loss protocols

Intestinal microorganisms change their phenotype and virulence by sensing the various adverse signals generated during intestinal stress, shifting from a commensal to a pathogenic mode and causing damage to the organism (72)