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Dosing melatonin at 0.3 mg daily for IBS-C and 3.0 mg for IBS-D may benefit patients with IBS [164]
IL-1 can enhance the neuronal production of A and induce protein phosphorylation, the blocking of which can alleviate neuroinflammation by reducing A levels and activation (94,95)
doi: 10.4049/jimmunol.1601199 146 NishimuraNTomiyasuNTorigoeSMizunoSFukanoHIshikawaEet al
doi: 10.1016/j.biopha.2016.11.006 149 GaoFYuanQGaoLCaiPZhuHLiuRet al
DasTRamezaniMSneadDFollmerCChungPLeeKYet al
