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AOD9604 did not stimulate the production of IGF-1 in any of the systems studied, and elicits its fat-reducing effects without inducing insulin resistance a key pharmacological distinction from intact hGH that makes it a uniquely clean research tool for studying lipolytic mechanisms in isolation

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doi: 10.1152/ajpregu.00051.2016

doi: 10.1016/j.rmed.2019.07.016 [DOI] [PubMed] [Google Scholar] 17.Hill AT, Sullivan AL, Chalmers JD, et al

For this reason the nasal spray format was developed as a tool for research into the intranasal route, and not as a finished preparation with an established action profile