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PubMed, Xiao, Yunjun, et al

Body composition shifts: Muscle can be harder to maintain while fat becomes easier to gain

This condition is an inherited form of sickle cell disease that affects red blood cells by producing abnormal hemoglobin and decreasing the synthesis of beta-globin protein chains
B.Wills-KarpM.et al

Patients should be counseled that initial doses are subtherapeutic and primarily intended for tolerability
