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Cecal levels of Akkermansia muciniphila have been strongly correlated with physiological metrics including glycemia and insulinemia 89 , and Akkermansia has correlated negatively with obesity-related measures 90 and has been implicated in DIO prevention 91,92

Funding: This work was supported in part by the Ontario College of Pharmacists through funding in support of the Pharmacy5in5 program

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Preparation of yuanhuacine and relative daphne diterpene esters from Daphne genkwa and structureactivity relationship of potent inhibitory activity against DNA topoisomerase I