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Muscles may adapt faster than connective tissue, especially during periods of aggressive loading, high-frequency training, or rapid strength increases

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But thats little comfort when youre the one with it on the back of your legs

Similarly, recruitment of participants with severe hepatic impairment into the hepatic impairment study was challenging and, despite a third study site being added and the recruitment period being prolonged, it was not possible to complete recruitment of seven participants into the severe hepatic impairment group

Shibata et al., 1988