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The observed lack of a significant accumulation of PHN in brain following the intraventricular administration of (+)-amphetamine and the formation of appreciable amounts of PHN from (+)-POH in brain tissue in vivo supports the view that the aromatic hydroxylation of amphetamine following its systemic administration occurs predominantly in the periphery, and that POH is then transported through the blood-brain barrier, taken up by noradrenergic neurones in brain where (+)-POH is converted in the storage vesicles by dopamine -hydroxylase to PHN

However, the majority of TMAO is excreted unchanged in the urine within 24 hours, with only a small amount excreted in the feces (72) ( Figure 1 )

[DOI] [PMC free article] [PubMed] [Google Scholar] Kalivas PW, Volkow ND

Protein concentration, solubility, and hydrophobicity can significantly influence this process [21,23,49]