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[DOI] [PMC free article] [PubMed] [Google Scholar] Noctor G., Gomez L., Vanacker H., Foyer C.H

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The clinical evidence for Rhodiola rosea is supported by multiple randomized, double-blind, placebo-controlled trials, including a phase III study evaluating the standardized extract SHR-5, which demonstrated statistically significant improvements in depressive symptoms with a favorable tolerability profile

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Poor safety performance increasingly risks LP dissatisfaction, negative ESG (environmental, social, and governance) ratings, and impaired fundraising potential, especially as ESG scrutiny intensifies (safety falls under social)

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