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10.1016/j.transci.2008.01.004 31 ChikazawaH.NishiyaK.MatsumoriA.HashimotoK

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But elimination diet therapy is not 100% effective

A clinical study has shown that cream with niacinamide enhances skin barrier function before application of 0.025% Vitamin A and significantly reduces the skin irritation such as dryness or peeling, burning, and stinging

Another option is the formation of urea between the amine of the intermediate and the target ligand using 4-nitrophenyl chloroformate
