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Description
We summarize potential use by injury mechanism, therapeutic timing, route of administration, monitoring strategy, safety considerations, and evidence level

Activated Akt initiates the mammalian rapamycin (mTOR) pathway, reprogramming energy metabolism from oxidative phosphorylation to glycolysis
Phase I metabolism is characterized by functionalization of the drug via one or more of the reactions: Oxidation (electron removal, dehydrogenation, or oxygenation) Reduction (electron addition, hydrogenation, or removal of oxygen) Hydration/dehydration (hydrolysis, and addition or removal of water) These transformations are carried out in the endoplasmic reticulum of hepatocytes and the most prominent Phase I reactions are oxidations

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Kids 1-3 Years 0.9 mcg
