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A 12-month clinical trial demonstrated a significant reduction in VPT in patients treated with C-peptide compared with placebo

Yes, alprostadil is a medication that comes in topical form

Applying a systems approach to thyroid physiology: Looking at the whole with a mitochondrial perspective instead of judging single TSH values or why we should know more about mitochondria to understand metabolism

All patients that satisfied these criteria were included, resulting in a final sample of 40 hypothyroidism (age mean 46 years, range 20 79 years, 4 males) and 12 CFS (mean age 43 years, range 23 68 years, 3 males) patients

doi: 10.1016/j.cmet.2015.09.026