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Furthermore, peripheral blood monocyte RNA sequencing in 12 healthy controls and 44 untreated MS patients revealed that the NLRP3 inflammasome of monocytes in primary progressive MS patients was overactivated [83]

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Specifically, we used PharmMapper [767] that uses a reverse pharmacophore mapping approach and requires a 3D structure (mol2 or sdf format) for ligand input, SwissTargetPrediction [768] that examines 2D and 3D molecular similarity, and SuperPred 3.0 [769] that uses machine learning models for prediction

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