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During ferroptosis, heme oxygenase 1 (Hmox1) is up-regulated with increased free iron release from cardiomyocytes, and then left ventricular remodeling would be triggered, causing severely impaired function of left ventricular in MI patients (Song et al., 2021) (Figure 1)

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This is the first large, population-based study linking vitamin B12 deficiency to acid-suppressing medications, which are among the most commonly used pharmaceuticals in the United States