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It works through a unique mechanism involving the activation of two different types of receptors in the body: the glucagon-like peptide-1 (GLP-1) receptor and the glucose-dependent insulinotropic polypeptide (GIP) receptor

However, preclinical studies demonstrate therapeutic effects with once-daily or even less frequent administration, suggesting tissue distribution, receptor binding, or cellular signaling effects extend beyond plasma clearance

This pattern is common, predictable, and manageable

Nature 550 , 529533 (2017)

Balance exercises, controlled movements, sport-specific drills restore proprioception and coordination reducing future injury risk