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In addition to limited absorption via the IF, the intake of high-dose supplements leads to passive diffusion, i.e., the vitamin can freely enter the bloodstream without IF binding and receptor uptake

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Galloway TJ, Zhang QE, Nguyen-Tan PF, Rosenthal DI , Soulieres D, Fortin A, Silverman CL, Daly ME, Ridge JA, Hammond JA, Le QT
The body interprets rapid fat loss as a significant stressor, releasing inflammatory mediators as part of the adaptive response
