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Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain
The practical consequence is that dose frequency is governed by downstream signalling windows, not plasma kinetics
Reproduction 149 , R8189 (2015)
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Pathway models based on the functional importance of aspartate for glutamate synthesis suggest the possibility of interacting pathways for biosynthesis and degradation of glutamate and GABA and the use of transamination as the default mechanism for initiation of glutamate oxidation
