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The Cochrane Database of Systematic Reviews (3) CD004326
Very helpful I take the C shots all winter and they really help keep me healthy and from getting any colds and such

3-Year Shelf Life: Ensures product stability and efficacy for up to 3 years when stored properly

As the needle reaches the trigger point, you may feel a brief deep ache or cramping sensation, followed by the local twitch response (a quick involuntary muscle jump)

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