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Common reasons for deficiency include: Low intake particularly diets low in whole grains, legumes, leafy greens or animal products Gut health issues like low stomach acid, SIBO, coeliac disease, IBD, or other factors affecting absorption Medications such as the contraceptive pill, metformin or antacids, which can deplete B vitamins Chronic stress increases demand for certain b vitamins, including B5 and B6 Vegan or vegetarian diets higher risk of B12 deficiency, which can be corrected through supplementation Genetic reasons some mutations on certain genes can increase a persons need for B vitamins This is why I always recommend testing before supplementing

An open letter from a number of concerned health professionals and organisations states: In over 60 years of vegan experimentation only B12 fortified foods and B12 supplements have proven themselves as reliable sources of B12, capable of supporting optimal health. How to Absorb Sufficient Vitamin B12 So, to make sure we cover all of our bases, we should incorporate B12 in a number of different forms at different times throughout the day

Even if youre using vitamin B12 to help you lose weight, it is best not to overdo it as there are side effects of upping the dosage

Some patients continue with weekly injections for 6 months or longer, then transition to biweekly or monthly maintenance

(2020) Selection and progression of unimolecular agonists at the GIP, GLP-1, and glucagon receptors as drug candidates