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5c,d), many of these genes underwent duplication events in the lineage leading to the bobtail squid and prominently in the cephalopod lineage (Fig
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Our results uncover a new noncanonical function of PKM2 as a transcriptional coactivator of Nrf2, which cooperates with its metabolic function to divert glucose flux into the pentose phosphate pathway 55 and thereby generates sufficient GSH for ROS detoxification

Semaglutide, tirzepatide, and the newer triple-agonist retatrutide work primarily by mimicking the incretin hormone GLP-1, which signals satiety to the brain

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