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Furthermore, epithelial cells with mutated NOD2, have an inappropriate response to a sensor of a cell wall component of Gram-positive bacteria (muramyl dipeptide, MDP) whose stimulation determines the production of pro-inflammatory mediators (338341)

Cellular glutathione plays a major role in the defence against redox cycling-derived oxidative stress, either by direct interaction with ROS, RNS and electrophiles, or by acting as a co-factor for various enzymes 11,12

During the transcellular migration, endothelial cells generate migratory cupsmicrovillus-like projections that rise along the sides of the neutrophil, eventually extending in vivo to envelop the neutrophil within a dome-like structure