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The synergy between PAH exposure and other ESCC risk factors (alcohol consumption, hot beverage intake, nutritional deficiencies) may explain the particularly high incidence in populations with multiple concurrent exposures
While this mechanism remains speculative, the underlying physiology of cryotherapy-induced blood flow changes supports the concept
Vitamin D insufficiency as a potential culprit in critical COVID-19 patients

Overall, we hope that this review encourages researchers to critically evaluate their choice of activity assays for flavoprotein oxidases or other redox enzymes, to develop new assay methodologies, and to explore underutilized or overlooked assays described in the literature

It is crucial in the occurrence, development, drug resistance, and potential therapeutic strategies of cancer
