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Supplementation with folic acid has been shown to increase global methylation levels, particularly LINE-1 repetitive element methylation, in populations at risk for folate deficiency [34,35]

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YC was supported by funding from the Key Specialty Facilities of Jiangsu Province, Gynecology Department (Grant# 41007) and The Second Affiliated Hospital of Soochow University, Department of Gynecology Clinical Trial Institution Capacity Improvement Project (Grant# SLT2023033)

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