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Overall, nine studies (six clinical studies, two case series, and one survey) were included

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Common solvents include bacteriostatic water, sterile saline, acidic buffers, and compatible analytical solvents

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Pannexin-1 channels are increasingly recognized as conduits for ATP release, and experimental blockade of Panx1 has been shown to attenuate peripheral inflammatory pain, underscoring their contribution to nociceptive amplification when inflammation is present [43,45]