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however, the effect was biphasic, progressing to an eventual APD decrease within 15 min of treatment (Xu and Rozanski, 1998)

doi: 10.1515/jpem-2020-0642

A meta-nalysis showed that, compared with placebo/no intervention, the treatment with acetyl-l-carnitine significantly decreased the symptoms of depression, with fewer adverse events than those seen with established antidepressants [94]
