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In this review, we discuss the roles of TDLNs in cancer metastasis, the impact of cancer cell progression and invasion on the LN immune microenvironment and the function of TDLNs in immunotherapy, as well as the opportunities and challenges in targeting LN metastasis for improving patient care

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While other members of this family, such as IL-17A and IL-17F, are primarily associated with neutrophilic inflammation, proinflammatory cytokine induction, and type 1 immunity, IL-25 uniquely promotes type 2 immune responses, including eosinophilic inflammation and the excessive production of IL-4, IL-5, and IL-13 [36]

881 - 892, Journal articles | 2018 Cui C

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