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The comparison illustrates the difference between extensive clinical validation and promising but unvalidated preclinical data

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It results from damage to the nerves of the hands and feet, causing pain and loss of function

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The HGF gene is mapped on the long arm of chromosome 7 of q21.1, and alternative splicing results in multiple transcripts, at least one of which encodes an inactive pre-pro-HGF

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If used in these patients, more frequent monitoring is required because of the potential for erratic or blunted absorption

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Grade: Research-use only

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