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Danthron upregulated adiponectin receptor 2 (AdipoR2) expression to, on the one hand, activate the AMPK pathway and, on the other hand, enhance the nuclear translocation of the PPAR/retinoid X receptor (RXR) heterodimer and bind with the AdipoR2 promoter, thereby promoting fatty acid oxidation, mitochondrial biogenesis, and energy expenditure in HFD-induced MASLD mice model [26]

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