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In the BTBR mouse model of autism, mGluR5 antagonist MPEP decreased repetitive self-grooming, whereas in three cohorts of BTBR mice, another antagonist of mGluR5, GRN-259, decreased repetitive behaviors

Indeed, anaerobic bacteria can degrade the CVM (72), and thus could enhance indirectly NET production through the lifting of NET release inhibition induced by mucins

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GPR4 knockout improves renal ischemiareperfusion injury and inhibits apoptosis via suppressing the expression of CHOP

1 Their basic structures consist of bicyclic skeletons, carboxylic acids, and keto groups at positions 3 and 4, respectively, which are necessary for their pharmacological activity 2,3 (Figure 1)