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Moreover, LF regulates body fat metabolism limiting obesity (probable downregulation of adipogenic genes and upregulation of fatty acid synthase and acetyl CoA carboxylase in adipocytes) [123,124] and glucose metabolism in patients with type 2 diabetes mellitus via improvement of the insulin-signaling response in adipocytes (up-phosphorylation of Akt serine 473 and up-expression of glucose transport 4 and insulin receptor 1) [107,124,125,126]

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However, peptides have intrinsic weak points, and they did not provide encouraging results in vivo , likely due to their physical, chemical and structural instability and low membrane permeability (112, 119, 121)

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