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However, in cocaine addiction, most of the research focusing on mechanisms of action has implicated the modulation of the cystineglutamate antiporter by NAC as the most likely cause of benefit.26,82,83 Whereas there are similarities across these disorders with alterations to oxidative biology and neurotransmission, and changes in glutamate-dependent long-term potentiation and neuronal plasticity,84 perhaps the heterogeneity of the underlying pathologies, especially in brain regions implicated, may lead to the revelation of different actions of NAC depending on the disorder

A glutathione amino acid precursor (GAP) blend increased the glutathione reduced monomers (GSH) oxidized dimers glutathione disulfide (GSSG) ratio, a surrogate measure for oxidative damage repair capacity

763 Cottonseed oil significantly improves MCAO/R induced neurological dysfunction in male rats by reducing infarct size and neuron damage and maintaining BBB integrity

Among the specific cancers examined, only lung cancer incidence was significantly higher in patients treated with ARBs

Because there is a lack of experimentation on dose-response relationships within this AOP, we propose that it is a qualitative AOP