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doi: 10.1146/annurev.psych.52.1.471 4

Oral drugs may be better absorbed if taken on an empty stomach to prevent peptide degradation resulting from food

This method by passes the digestive system, allowing for more efficient absorption and increased effectiveness compared to oral supplements

doi: 10.3390/nu8050307

Some peptides exert effects through signaling in the gut and systemic circulation rather than direct tissue delivery
