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Research has discovered that the accumulation of -2HG caused by IDH1 mutations can inhibit the amino transferases branched-chain aminotransferase 1 and branched-chain aminotransferase 2, reducing glutamate levels and increasing the synthesis of glutathione, thereby affecting tumor cell survival [149]

If you're new to the concept, our guide to liposomal delivery explains how this format is designed to support bioavailability

The combined impact on vascular tone, coagulation, and oxygen utilization is a major contributor to the development of shock and multi-organ dysfunction syndrome

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