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metformin b12 injections assalamuwalaikum, can reduce absorption of Vitamin B12, and this is a well-established long-term adverse effect. Mechanism Metformin mainly interferes with: Calcium-dependent absorption of the intrinsic factor–B12 complex in the terminal ileum Vitamin B12 Injection – Manufacturer
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Because its a water-soluble vitamin, B12 wont stay in your system for long, which means its essential you replenish your levels through diet or supplementation

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