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The feedback regulation of PGC-1 by Fundc1 deficiency was also observed in primary cardiomyocytes, and the increased mRNA levels of PGC-1, NRF1, and TFAM in CK2-deleted cells were diminished when FUNDC1 was knocked down, suggesting that mitobiogenesis and mitochondrial turnover are accelerated by FUNDC1-mediated mitophagy [236]

10ml or more should be split and given at successive intramuscular and subcutaneous sites

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Molecular weight: ~1815.1 g/mol