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In vitro skin irritation test provides an alternative to animal testing and allows the screening of compounds before they undergo clinical testing

Protein kinase C bidirectionally modulates I h and hyperpolarization-activated cyclic nucleotide-gated (HCN) channel surface expression in hippocampal pyramidal neurons

Funding This study was supported by LiaoNing Revitalization Talents Program (XLYC1807131), the Science and Technology Innovation Foundation of Dalian (2020JJ27SN070) and the open project of Key Laboratory for Micro/Nano Technology and System of Liaoning Province, Dalian University of Technology (20210101)

For best results, take 10 pumps (2mL) under the tongue daily, or mix with 8 oz of cold water

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