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Leading theories hint at the issue being related to the formation of new bone-forming cells, known as osteoblasts (R)
Charge-Controlled Nanoprecipitation as a Modular Approach to Ultrasmall Polymer Nanocarriers: Making Bright and Stable Nanoparticles

A lack of methylfolate means this conversion cant happen as it should

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Journal of Clinical Biochemistry and Nutrition, 61 (1), 3339