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Curr Pharm Des 25(16):18281846 Shanmugam T, Selvaraj M, Poomalai S (2016) Epigallocatechin gallate potentially abrogates fluoride induced lung oxidative stress, inflammation via Nrf2/Keap1 signaling pathway in rats: an in-vivo and in-silico study

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Inhibitors do not convert TGR into an NADPH oxidase Several covalent inhibitors of TGR are electrophilic compounds reacting with the Sec residue at the C-terminus, which induce a transition in the enzyme from an antioxidant to a pro-oxidant with increased NADPH consumption 20,45