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Few of these patients developed severe hearing loss requiring rehabilitation

The empirical solubility measurements showed approximately 102 folds higher aqueous solubility for the glutathione-epothilone conjugate (0.127 mg/ml) compared to unmodified Epothilone (0.00125 mg/ml)

Gerstein, Ed S

Sharma P, Piya S, Baran N, Zal A, Zhang Q, Munck J, Dao KH, Sims M, Andreeff M , Borthakur G

developed computational models capable of predicting the clinically relevant physicochemical properties of nanocarriers and their mRNA payload delivery efficiency in human cells[215]
