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The active ingredient loses effectiveness when pre-mixed and could harbour bacteria if left in the heat

They are essentially the same

Low melanin content means that laser energy passes through the hair shaft without being absorbed, failing to generate the temperatures necessary for follicular coagulation

Melanin is a pigment that gives skin its color and also acts as a natural sunscreen, protecting the skin from the harmful effects of ultraviolet (UV) radiation

Funding This work was supported by the Open Project of National Major Science and Technology Infrastructure of Translational Medicine (TMSK-2021-404), the Youth Innovation Research Foundation (A1-U21-205-01010109), the National Natural Science Foundation of China (81972932), and the program of Shanghai E-research Institute of Bioactive Constituents in Traditional Chinese Medicine