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Bidirectional communication between the ENS and the CNS, the gut-brain axis, integrates digestive and defensive functions of the gut with those of other organs to maintain homeostasis (710) (FIGURE 1)

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A competent RCT research question will encompass the participant population, the therapy/clinical intervention, outcomes, and it typically questions the effectiveness of one therapy versus another (or placebo) [17, 18]

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