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Moderate exercise maintains ROS at normal physiological levels, where ROS act as key signaling molecules to activate the Nrf2 pathway and upregulate the expression of endogenous antioxidants such as HO-1, SOD, and GPx (Merry and Ristow, 2016)

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analyzed the relationship between chronic stress and breast cancer, in particular the molecular mechanism by which chronic stress promotes the development of breast cancer [308]

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