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In models of retinal degeneration, Epitalon has been delivered via parabulbar injection, a technique that places the compound near the posterior eye to maximize local availability [64, 65]

Several approaches including chemical modifications, use of absorption and penetration enhancers, use of mucoadhesive polymers, formulation design, and use of enzyme inhibitors have been investigated to improve their bioavailability

Additionally, we are afraid that the estimated Ames results on MSPs may not be entirely relevant to human safety for the reasons described in the previous section (Application of ICH S2(R1))

Injectable B12, which is often recommended in severe deficiency cases, may cause more adverse effects, including diarrhea, itching, skin rash, headache, dizziness, nausea, or vomiting