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Less commonly, these agents have been associated with a slightly elevated risk of certain malignancies (e.g., non-melanoma skin cancer and lymphoma) and rare autoimmune-like conditions (e.g., drug-induced lupus, paradoxical psoriasis)
While 5-amino-1mq itself is not a stimulant, the enhanced energy production it supports could amplify stimulant effects
The R-domain is helical (residues 920929) in the C-terminal segment and lacks secondary structure (residues 901919 and 930935) in the other

Synergistically interacting dopamine D1 and NMDA receptors mediate nonvesicular transporter-dependent GABA release from rat striatal medium spiny neurons
