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Research has indicated that compounds targeting TRP channels, such as vanillin, capsaicin and capsazepine, can reduce reactive astrocyte activity, which in turn can mitigate A toxicity in the early stages of AD 154

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Diabetologia 59 , 879894 (2016)

doi: 10.1097/BSD.0000000000001051

There is considerable phenotypic and genetic overlap between ID and ASD, particularly in areas like cognitive impairments, social communication challenges, and behavioral difficulties, with both disorders sharing common epigenetic regulatory mechanisms